- Title
- miRNA cargo in circulating vesicles from neurons is altered in individuals with schizophrenia and associated with severe disease
- Creator
- Barnett, Michelle M.; Reay, William R.; Geaghan, Michael P.; Kiltschewskij, Dylan J.; Green, Melissa J.; Weidenhofer, Judith; Glatt, Stephen J.; Cairns, Murray J.
- Relation
- NHMRC.1147644 http://purl.org/au-research/grants/nhmrc/1147644 | 1121474 http://purl.org/au-research/grants/nhmrc/1121474
- Relation
- Science Advances Vol. 9, Issue 48, no. eadi4386
- Publisher Link
- http://dx.doi.org/10.1126/sciadv.adi4386
- Publisher
- American Association for the Advancement of Science (AAAS)
- Resource Type
- journal article
- Date
- 2023
- Description
- While RNA expression appears to be altered in several brain disorders, the constraints of postmortem analysis make it impractical for well-powered population studies and biomarker development. Given that the unique molecular composition of neurons are reflected in their extracellular vesicles (EVs), we hypothesized that the fractionation of neuron derived EVs provides an opportunity to specifically profile their encapsulated contents noninvasively from blood. To investigate this hypothesis, we determined miRNA expression in microtubule associated protein 1B (MAP1B)-enriched serum EVs derived from neurons from a large cohort of individuals with schizophrenia and nonpsychiatric comparison participants. We observed dysregulation of miRNA in schizophrenia subjects, in particular those with treatment-resistance and severe cognitive deficits. These data support the hypothesis that schizophrenia is associated with alterations in posttranscriptional regulation of synaptic gene expression and provides an example of the potential utility of tissue-specific EV analysis in brain disorders.
- Subject
- brain disorders; schizophrenia; extracellular vesicles (EVs); miRNA
- Identifier
- http://hdl.handle.net/1959.13/1497353
- Identifier
- uon:54330
- Identifier
- ISSN:2375-2548
- Rights
- © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/). This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Language
- eng
- Full Text
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